Total AKAP 10 Cell-Based Colorimetric ELISA Kit
- 货号:KA3465C
- 应用:ELISA
- 种属:Human;Mouse;Rat
- 基因名称:
- AKAP10
- Human Gene Id:
- 11216
- Human Swiss Prot No:
- O43572
- Mouse Swiss Prot No:
- O88845
- 储存:
- 2-8°C/6 months
- 其他名称:
- A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10)
- 检测方法:
- Colorimetric
- 背景:
- domain:RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.,function:Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.,similarity:Contains 2 RGS domains.,subcellular location:Predominantly mitochondrial but also membrane associated and cytoplasmic.,
- 功能:
- protein localization,
- 细胞定位:
- Mitochondrion . Membrane . Cytoplasm . Predominantly mitochondrial but also membrane associated and cytoplasmic.
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