Total Midline-1 Cell-Based Colorimetric ELISA Kit

  • 货号：KA3457C
  • 应用：ELISA
  • 种属：Human;Mouse;Rat
    • 基因名称：
    • MID1
    • Human Gene Id：
    • 4281
    • Human Swiss Prot No：
    • O15344
    • Mouse Swiss Prot No：
    • O70583
    • 储存：
    • 2-8°C/6 months
    • 其他名称：
    • Midline-1 (EC 6.3.2.-) (Midin) (Midline 1 RING finger protein) (Putative transcription factor XPRF) (RING finger protein 59) (Tripartite motif-containing protein 18)
    • 检测方法：
    • Colorimetric
    • 背景：
    • disease:Defects in MID1 are the cause of Opitz syndrome type I (OS-I) [MIM:300000]. OS-I is an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. OS-I mutations produce proteins with a decreased affinity for microtubules.,function:May have E3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation.,induction:A retroviral element acts as an alternative tissue-specific promoter for this gene. The LTR of an HERV-E element enhances the expression in placenta and embryonic kidney.,PTM:Phosphorylated on serine and threonine residues.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 COS domain.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 2 B box-type zinc fingers.,subcellular location:Microtubule-associated. It is associated with microtubules throughout the cell cycle, co-localizing with cytoplasmic fibers in interphase and with the mitotic spindle and midbodies during mitosis and cytokinesis.,subunit:Homodimer or heterodimer with MID2. Interacts with IGBP1.,tissue specificity:In the fetus, highest expression found in kidney, followed by brain and lung. Expressed at low levels in fetal liver. In the adult, most abundant in heart, placenta and brain.,
    • 功能：
    • microtubule cytoskeleton organization, proteolysis, cytoskeleton organization, microtubule-based process, negative regulation of microtubule depolymerization, pattern specification process, macromolecule catabolic process, negative regulation of organelle organization, modification-dependent protein catabolic process, protein catabolic process,regulation of microtubule polymerization or depolymerization, negative regulation of microtubule polymerization or depolymerization, regulation of microtubule depolymerization, regulation of microtubule-based process, regulation of organelle organization, negative regulation of protein complex disassembly, regulation of protein complex disassembly, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process, negative regulation of cellular component organization, regulation of
    • 细胞定位：
    • Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle . Microtubule-associated. It is associated with microtubules throughout the cell cycle, co-localizing with cytoplasmic fibers in interphase and with the mitotic spindle and midbodies during mitosis and cytokinesis.
    • 组织表达：
    • In the fetus, highest expression found in kidney, followed by brain and lung. Expressed at low levels in fetal liver. In the adult, most abundant in heart, placenta and brain.

    相关报价

    • 货号：
    • KA3457C
    • 规格：
    • 96 / well
    • 价格：
    • ¥3300
    • 货期：
    • 预计发货时间为
      2024-08-02
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