Total TIF1α Cell-Based Colorimetric ELISA Kit
- 货号：KA3456C
- 应用：ELISA
- 种属：Human;Mouse
- 其他名称：
- Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (Tripartite motif-containing protein 24)
- 背景：
- disease:A chromosomal aberration involving TIF1 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t(7;10)(q32;q11) with RET. The translocation generates the TIF1/RET (PTC6) oncogene.,function:Interacts selectively in vitro with the AF2-activating domain of the estrogen receptors. Association with DNA-bound estrogen receptors requires the presence of estradiol.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 bromo domain.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 2 B box-type zinc fingers.,subunit:Interacts with CBX1 and CBX3 (By similarity). Interacts with NR3C2.,
- 功能：
- transcription, transcription, DNA-dependent, transcription initiation, regulation of transcription, DNA-dependent,transcription from RNA polymerase II promoter, protein complex assembly, protein amino acid phosphorylation,phosphorus metabolic process, phosphate metabolic process, negative regulation of cell proliferation, negative regulation of biosynthetic process, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression,negative regulation of gene expression, phosphorylation, negative regulation of transcription, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, regulation of
- 细胞定位：
- Nucleus . Cytoplasm . Mitochondrion . Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear. Translocated from nucleus to mitochondria to mediate antiviral immunity (PubMed:32324863). .
