Total CD40 Cell-Based Colorimetric ELISA Kit
- 货号：KA3402C
- 应用：ELISA
- 种属：Human;Mouse
- 其他名称：
- Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)
- 背景：
- alternative products:Additional isoforms seem to exist,disease:Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3) [MIM:606843]. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.,function:Receptor for TNFSF5/CD40LG.,online information:CD40 entry,online information:CD40 mutation db,similarity:Contains 4 TNFR-Cys repeats.,subunit:Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:B-cells and in primary carcinomas.,
- 功能：
- regulation of DNA recombination, cell activation, regulation of cytokine production, positive regulation of cytokine production, regulation of immunoglobulin production, positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, regulation of immune effector process, regulation of production of molecular mediator of immune response, regulation of leukocyte mediated immunity, regulation of lymphocyte mediated immunity, regulation of B cell mediated immunity, immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway, regulation of adaptive immune response, regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, regulation of immunoglobulin mediated immune response, protein complex assemb
- 细胞定位：
- [Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.
- 组织表达：
- B-cells and in primary carcinomas.
