Total BM28 Cell-Based Colorimetric ELISA Kit
- 货号：KA3319C
- 应用：ELISA
- 种属：Human;Mouse
- 其他名称：
- DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
- 背景：
- function:Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.,PTM:Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,subunit:Interacts with DBF4 (By similarity). Interacts with MYST2. May interact with MCM10.,
- 功能：
- DNA metabolic process, DNA replication, DNA-dependent DNA replication, DNA unwinding during replication, DNA replication initiation, DNA packaging, chromatin organization, chromatin assembly or disassembly, nucleosome assembly, transcription, cell cycle, chromatin assembly, DNA geometric change, DNA duplex unwinding, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly, nucleosome organization,macromolecular complex subunit organization, regulation of transcription, chromosome organization, macromolecular complex assembly, protein-DNA complex assembly,
- 细胞定位：
- Nucleus . Chromosome . Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. .
