ImmunoWay Biotechnology Company |抗体|病理抗体|诊断抗体

Total Endoplasmin Cell-Based Colorimetric ELISA Kit

其他名称：
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog)

背景：
function:Molecular chaperone that functions in the processing and transport of secreted proteins. Has ATPase activity.,PTM:Phosphorylated.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.,

功能：
response to hypoxia, protein folding, proteolysis, ubiquitin-dependent protein catabolic process, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, anti-apoptosis, protein localization,macromolecule catabolic process, proteasomal protein catabolic process, regulation of cell death, protein transport,cellular homeostasis, modification-dependent protein catabolic process, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, protein catabolic process, ER-associated protein catabolic process, homeostatic process, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, proteasomal ubiquitin-dependent protein catabolic process, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolec

细胞定位：
Endoplasmic reticulum lumen . Sarcoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .