• 基因名称：
• GZMB/GZMH

• Human Swiss Prot No：
• P10144/P20718

• 储存：
• 2-8°C/6 months

• 检测方法：
• Colorimetric

• 背景：
• catalytic activity:Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-.,function:This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.,induction:By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subcellular location:Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.,

• 功能：
• proteolysis, apoptosis, cell structure disassembly during apoptosis, cleavage of lamin, cleavage of cytoskeletal proteins during apoptosis, cell death, programmed cell death, death, cytolysis, cellular component disassembly,

• 细胞定位：
• Secreted . Cytolytic granule . Delivered into the target cell by perforin (PubMed:20038786). .

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