Total Cyclin E1 Cell-Based Colorimetric ELISA Kit

  • 货号:KA3238C
  • 应用:ELISA
  • 种属:Human;Mouse;Rat
    • 基因名称:
    • CCNE1
    • Human Gene Id:
    • 898
    • Human Swiss Prot No:
    • P24864
    • Mouse Swiss Prot No:
    • Q61457
    • 储存:
    • 2-8°C/6 months
    • 其他名称:
    • G1/S-specific cyclin-E1
    • 检测方法:
    • Colorimetric
    • 背景:
    • function:Essential for the control of the cell cycle at the G1/S (start) transition.,PTM:Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the cyclin family. Cyclin E subfamily.,subunit:Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1.,tissue specificity:Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.,
    • 功能:
    • G1/S transition of mitotic cell cycle, mitotic cell cycle, ovarian follicle development, antral ovarian follicle growth, liver development, reproductive developmental process, regulation of transcription, DNA-dependent, cell cycle, intracellular signaling cascade, sex differentiation, response to nutrient, gonad development, female gonad development,response to endogenous stimulus, response to hormone stimulus, positive regulation of biosynthetic process,response to extracellular stimulus, response to organic substance, response to organic nitrogen, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, response to organic cyclic substance, response to purine, cell cycle process, cell cycle phase,ovulation cycle process, steroid hormone receptor signaling pathway, androgen receptor signali
    • 细胞定位:
    • Nucleus .
    • 组织表达:
    • Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.