Total Catenin-α E/N Cell-Based Colorimetric ELISA Kit
- 货号:KA3213C
- 应用:ELISA
- 种属:Human;Mouse;Rat
- 基因名称:
- CTNNA1/CTNNA2
- Human Swiss Prot No:
- P35221/P26232
- 储存:
- 2-8°C/6 months
- 检测方法:
- Colorimetric
- 背景:
- disease:Abnormalities of alpha-catenin are involved in the process of cancer invasion and metastasis.,function:Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation.,PTM:Sumoylated.,similarity:Belongs to the vinculin/alpha-catenin family.,subcellular location:Found at cell-cell boundaries and probably at cell-matrix boundaries.,subunit:Binds MLLT4 and F-actin (By similarity). Interacts directly with PSEN1 and CTNNB1 to form part of the PSEN1/cadherin/catenin adhesion complex. Interacts with ARHGAP21 and with JUB.,tissue specificity:Expressed ubiquitously in normal tissues.,
- 功能:
- cell-cell junction assembly, cell adhesion, biological adhesion, cell junction assembly, cell junction organization, apical junction assembly, cell-cell junction organization,
- 细胞定位:
- [Isoform 1]: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.; [Isoform 3]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
- 组织表达:
- Expressed ubiquitously in normal tissues.
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