Total Bim Cell-Based Colorimetric ELISA Kit
- 货号：KA3048C
- 应用：ELISA
- 种属：Human;Mouse;Rat
- 其他名称：
- Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)
- 背景：
- domain:The BH3 motif is required for Bcl-2 binding and cytotoxicity.,function:Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.,similarity:Belongs to the Bcl-2 family.,subcellular location:Associated with intracytoplasmic membranes.,subunit:Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK.,tissue specificity:Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.,
- 功能：
- urogenital system development, in utero embryonic development, leukocyte homeostasis, B cell homeostasis, B cell apoptosis, kidney development, lymphocyte homeostasis, myeloid cell homeostasis, immune system development,reproductive developmental process, apoptosis, induction of apoptosis, cell adhesion, cell-matrix adhesion, gamete generation, spermatogenesis, sensory organ development, sex differentiation, cell death, gonad development, male gonad development, induction of apoptosis by extracellular signals, activation of pro-apoptotic gene products, post-embryonic development, embryonic development ending in birth or egg hatching, post-embryonic morphogenesis,regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death,death, sexual reproduction, biological adhesion, mammary gland development, cell-substrate adhesion, multicell
- 细胞定位：
- Endomembrane system ; Peripheral membrane protein . Associated with intracytoplasmic membranes. .; [Isoform BimEL]: Mitochondrion. Translocates from microtubules to mitochondria on loss of cell adherence.; [Isoform BimL]: Mitochondrion.; [Isoform BimS]: Mitochondrion.; [Isoform Bim-alpha1]: Mitochondrion.
- 组织表达：
- Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
