Phospho Abl (Y412) Cell-Based Colorimetric ELISA Kit

  • 货号：KA1777C
  • 应用：ELISA
  • 种属：Human;Mouse
    • 基因名称：
    • ABL1
    • Human Gene Id：
    • 27
    • Human Swiss Prot No：
    • P42684
    • Mouse Swiss Prot No：
    • Q4JIM5
    • 储存：
    • 2-8°C/6 months
    • 其他名称：
    • Abelson tyrosine-protein kinase 2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)
    • 检测方法：
    • Colorimetric
    • 背景：
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium or manganese.,enzyme regulation:Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the amino-terminal cap, and contributions from an amino-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML).,function:Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,tissue specificity:Widely expressed.,
    • 功能：
    • protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cytoskeleton organization, actin filament organization, cell adhesion, phosphorylation, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, biological adhesion, actin filament-based process, actin cytoskeleton organization, positive regulation of catalytic activity, positive regulation of molecular function, actin filament bundle formation, regulation of oxidoreductase activity, positive regulation of oxidoreductase activity,
    • 细胞定位：
    • Cytoplasm, cytoskeleton.
    • 组织表达：
    • Widely expressed.

    相关报价

    • 货号：
    • KA1777C
    • 规格：
    • 96 / well
    • 价格：
    • ¥4700
    • 货期：
    • 预计发货时间为
      2024-12-11
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