Phospho MAPKAPK5 (T182) Cell-Based Colorimetric ELISA Kit

  • 货号：KA1752C
  • 应用：ELISA
  • 种属：Human;Mouse
    • 基因名称：
    • MAPKAPK5
    • Human Gene Id：
    • 8550
    • Human Swiss Prot No：
    • Q8IW41
    • Mouse Swiss Prot No：
    • O54992
    • 储存：
    • 2-8°C/6 months
    • 其他名称：
    • MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK)
    • 检测方法：
    • Colorimetric
    • 背景：
    • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:p38 alpha and beta-dependent phosphorylation increases its activity. Activated by stress-related extracellular stimuli; such as H(2)O(2), arsenite, anisomycin TNF alpha and also PMA and the calcium ionophore A23187; but to a lesser extent. In vitro, activated by SQSTM1.,function:Mediates stress-induced small heat shock protein 27 phosphorylation.,PTM:Phosphorylated on Thr-182; which is the regulatory phosphorylation site and is located on the T-loop/loop 12.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Also observed in the nucleus.,subunit:Interacts with SQSTM1.,tissue specificity:Expressed ubiquitously.,
    • 功能：
    • protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, phosphorylation,
    • 细胞定位：
    • Cytoplasm. Nucleus. Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.
    • 组织表达：
    • Expressed ubiquitously.

    相关报价

    • 货号：
    • KA1752C
    • 规格：
    • 96 / well
    • 价格：
    • ¥4700
    • 货期：
    • 预计发货时间为
      2024-12-08
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