• 基因名称：
• PAK3

• Human Gene Id：
• 5063

• Human Swiss Prot No：
• O75914

• Mouse Swiss Prot No：
• Q61036

• Rat Swiss Prot No：
• Q62829

• 储存：
• 2-8°C/6 months

• 其他名称：
• Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3)

• 检测方法：
• Colorimetric

• 背景：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,disease:Defects in PAK3 are the cause of mental retardation X-linked type 30 (MRX30) [MIM:300558]; also called X-linked mental retardation type 47 (MRX47). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,enzyme regulation:Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 and allows the kinase domain to adopt an active structure.,function:Key regulator of synapse formation and plasticity in the hippocampus.,PTM:Autophosphorylated when activated by CDC42/p21.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK.,tissue specificity:Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.,

• 功能：
• protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, phosphorylation,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.

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