• 基因名称：
• PRKD2

• Human Gene Id：
• 25865

• Human Swiss Prot No：
• Q9BZL6

• Mouse Swiss Prot No：
• Q8BZ03

• Rat Swiss Prot No：
• Q5XIS9

• 储存：
• 2-8°C/6 months

• 其他名称：
• Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2)

• 检测方法：
• Colorimetric

• 背景：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by diacylglycerol and phorbol esters.,function:Calcium-independent, phospholipid-dependent, serine- and threonine-specific protein kinase.,PTM:Autophosphorylated. Phorbol esters stimulates autophosphorylation. Phosphorylation of Ser-876 correlates with the activation status of the kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,tissue specificity:Widely expressed.,

• 功能：
• protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, phosphorylation,

• 细胞定位：
• Cytoplasm . Cell membrane . Nucleus . Golgi apparatus, trans-Golgi network . Translocation to the cell membrane is required for kinase activation. Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. .

• 组织表达：
• Widely expressed.

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