• 基因名称：
• ATF1

• Human Gene Id：
• 466

• Human Swiss Prot No：
• P18846

• Mouse Swiss Prot No：
• P81269

• 储存：
• 2-8°C/6 months

• 其他名称：
• Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36)

• 检测方法：
• Colorimetric

• 背景：
• disease:A chromosomal aberration involving ATF1 is associated with angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein.,disease:A chromosomal aberration involving ATF1 is associated with angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.,function:This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 KID (kinase-inducible) domain.,subunit:Binds DNA as a dimer.,

• 功能：
• transcription, regulation of transcription, DNA-dependent, regulation of transcription, regulation of RNA metabolic process,

• 细胞定位：
• Nucleus .

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