• Target：
• TGFβ RIII

• Gene Name：
• TGFBR3

• Protein Name：
• Transforming growth factor beta receptor type 3

• Human Gene Id：
• 7049

• Human Swiss Prot No：
• Q03167

• Mouse Gene Id：
• 21814

• Mouse Swiss Prot No：
• O88393

• Rat Gene Id：
• 29610

• Rat Swiss Prot No：
• P26342

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TGF beta Receptor III. AA range:801-850

• Specificity：
• TGFβ RIII Polyclonal Antibody detects endogenous levels of TGFβ RIII protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000. ELISA: 1:5000. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TGFBR3;Transforming growth factor beta receptor type 3;TGF-beta receptor type 3;TGFR-3;Betaglycan;Transforming growth factor beta receptor III;TGF-beta receptor type III

• Molecular Weight(Da)：
• 93kD

• Background：
• This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010],

• Function：
• function:Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.,PTM:Extensively modified by glycosaminoglycan groups (GAG).,similarity:Contains 1 ZP domain.,subcellular location:Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.,subunit:Interacts with TCTEX1D4.,

• Subcellular Location：
• Secreted. Secreted, extracellular space. Cell membrane ; Single-pass type I membrane protein . Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.

• Expression：
• Blood,Brain,Placenta,Tongue,

Exosomes derived from 5-fluorouracil-resistant colon cancer cells are enriched in GDF15 and can promote angiogenesis. Journal of Cancer J Cancer. 2020; 11(24): 7116–7126 WB Human 1 : 500 HCT-15/FU exosome

Hepatitis B Virus X Protein (HBx) Suppresses Transcription Factor EB (TFEB) Resulting in Stabilization of Integrin Beta 1 (ITGB1) in Hepatocellular Carcinoma Cells. Cancers Cancers. 2021 Jan;13(5):1181 WB Human HepG2 cell，SK-Hep-1 cell，HEK-293FT cell

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