CD28-FC recombinant protein

  • Catalog No.:YD3067
  • Reactivity:Human;
    • Purity:
    • >90% as determined by SDS-PAGE
    • Gene Name:
    • CD28
    • Protein Name:
    • T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28)
    • Sequence:
    • Amino acid:19-152,with FC tag.
    • Human Gene Id:
    • 940
    • Human Swiss Prot No:
    • P10747
    • Formulation:
    • Phosphate-buffered solution
    • Source:
    • Mammalian cells
    • Storage Stability:
    • -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
    • Other Name:
    • T-cell-specific surface glycoprotein CD28 ;TP44;CD antigen CD28;CD28;
    • Function:
    • Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).
    • Subcellular Location:
    • Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface .
    • Expression:
    • Expressed in T-cells and plasma cells, but not in less mature B-cells.