GATA-3-FC recombinant protein
- Catalog No.：YD3033
- Reactivity：Human;
- Purity：
- >90% as determined by SDS-PAGE
- Protein Name：
- Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3)
- Formulation：
- Phosphate-buffered solution
- Storage Stability：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- Other Name：
- Trans-acting T-cell-specific transcription factor GATA-3 ;GATA-binding factor 3;GATA3;
- Function：
- Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.
- Subcellular Location：
- Nucleus.
- Expression：
- T-cells and endothelial cells.
