CD303 (BDCA-2)-FC recombinant protein
- Catalog No.：YD3012
- Reactivity：Human;
- Purity：
- >90% as determined by SDS-PAGE
- Protein Name：
- C-type lectin domain family 4 member C (Blood dendritic cell antigen 2) (BDCA-2) (C-type lectin superfamily member 7) (Dendritic lectin) (CD antigen CD303)
- Sequence：
- Amino acid:45-213,with FC tag.
- Formulation：
- Phosphate-buffered solution
- Storage Stability：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- Other Name：
- C-type lectin domain family 4 member C ;Blood dendritic cell antigen 2;BDCA-2;C-type lectin superfamily member 7;Dendritic lectin;CD antigen CD303;CLEC4C;BDCA2;CLECSF11;CLECSF7;DLEC;HECL;UNQ9361/PRO34150;
- Function：
- Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283).
- Subcellular Location：
- Cell membrane ; Single-pass type II membrane protein .
- Expression：
- Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.
