Total UBA2 Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA3424C
- Applications:ELISA
- Reactivity:Human
- Gene Name:
- UBA2
- Human Gene Id:
- 10054
- Human Swiss Prot No:
- Q9UBT2
- Mouse Swiss Prot No:
- Q9Z1F9
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- SUMO-activating enzyme subunit 2 (EC 6.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B)
- Detection Method:
- Colorimetric
- Background:
- function:The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.,pathway:Protein modification; protein sumoylation.,similarity:Belongs to the ubiquitin-activating E1 family.,subunit:Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2.,
- Function:
- proteolysis, macromolecule catabolic process, modification-dependent protein catabolic process, protein catabolic process, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process, proteolysis involved in cellular protein catabolic process,
- Subcellular Location:
- Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
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