Synthesized peptide derived from human CD117 AA range: 1-100

The antibody can specifically recognize human CD117 protein.

KIT SCFR

C Kit;c-Kit;c-Kit Ligand;CD117;Kit;Kit Ligand;KIT oncogene;KIT proto oncogene receptor tyrosine kinase;KIT_HUMAN;Mast cell growth factor receptor;Mast/stem cell growth factor receptor Kit;MGF;p145 c-kit;PBT;Piebald trait protein;Proto oncogene c Kit;Proto oncogene tyrosine protein kinase Kit;Proto-oncogene c-Kit;SCF Receptor;SCFR;soluble KIT variant 1;Steel Factor Receptor;Stem cell factor receptor;tyrosine protein kinase Kit;Tyrosine-protein kinase Kit;v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog;v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

C Kit ;
c-Kit ;
c-Kit Ligand ;
CD117 ;
Kit ;
Kit Ligand ;
KIT oncogene ;
KIT proto oncogene receptor tyrosine kinase ;
KIT_HUMAN ;
Mast cell growth factor receptor ;
Mast/stem cell growth factor receptor Kit ;
MGF ;
p145 c-kit ;
PBT ;
Piebald trait protein ;
Proto oncogene c Kit ;
Proto oncogene tyrosine protein kinase Kit ;
Proto-oncogene c-Kit ;
SCF Receptor ;
SCFR ;
soluble KIT variant 1 ;
Steel Factor Receptor ;
Stem cell factor receptor ;
tyrosine protein kinase Kit ;
Tyrosine-protein kinase Kit ;
v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog ;
v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein ;
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor , also known as stem cell factor) . Mutations in this gene are associated with gastrointestinal stromal tumors , mast cell disease , acute myelogenous lukemia , and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Jul 2008] ,

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Disease:Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]. ,Disease:Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. ,Disease:Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT) . ,Function:This is the receptor for stem cell factor (mast cell growth factor) . It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K) . ,online information:CD117 entry ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains. ,subunit:Interacts with APS. Interacts with MPDZ (via the tenth PDZ domain) . Interacts with PTPRU. ,

Cytoplasmic , Membranous

>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Phospholipase D signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Hematopoietic cell lineage ;
>>Melanogenesis ;
>>Pathways in cancer ;
>>Acute myeloid leukemia ;
>>Breast cancer ;
>>Central carbon metabolism in cancer