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Thyroid hormone signaling pathway
The thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) and T3 enter the cell through transporter proteins. Although the major form of TH in the blood is T4, it is converted to the more active hormone T3 within cells. T3 binds to nuclear thyroid hormone receptors (TRs), which functions as a ligand-dependent transcription factor and controls the expression of target genes (genomic action). Nongenomic mechanisms of action is initiated at the integrin receptor. The plasma membrane alpha(v)beta(3)-integrin has distinct binding sites for T3 and T4. One binding site binds only T3 and activates the phosphatidylinositol 3-kinase (PI3K) pathway. The other binding site binds both T3 and T4 and activates the ERK1/2 MAP kinase pathway.
Product List
    Catalog
    Product
    Reactivity
    Applications
  • PRKACA (PT0438R) PT® Rabbit mAb
    Human,Mouse,Rat,
    WB,IHC,IF,IP,ELISA
  • PKAα cat (Phospho Ser338) Rabbit pAb
    Human,Mouse,Rat
    IHC,IF,ELISA
  • PKAβ Rabbit pAb
    Human,Mouse,Rat
    WB,IHC,IF,ELISA
  • Total PKAβ cat Cell-Based Colorimetric ELISA Kit
    Human,Mouse,Rat
    ELISA
  • PKAγ Rabbit pAb
    Human
    WB,IHC,IF,ELISA
  • Integrin αV Rabbit pAb
    Human,Mouse
    WB,IHC,IF,ELISA
  • Cleaved Integrin αV HC (Lys889) Rabbit pAb
    Human,Rat,Mouse,
    WB,ELISA
  • Cleaved ITGAV (light chain,Asp891) Rabbit pAb
    Human,Mouse
    WB,ELISA,IHC
  • Integrin β3 (PT0445R) PT® Rabbit mAb
    Human,Mouse,Rat,
    WB,IHC,IF,IP,ELISA
  • CD61 (ABT032) Mouse mAb
    Human,Mouse,
    IHC,ELISA
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