The thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) and T3 enter the cell through transporter proteins. Although the major form of TH in the blood is T4, it is converted to the more active hormone T3 within cells. T3 binds to nuclear thyroid hormone receptors (TRs), which functions as a ligand-dependent transcription factor and controls the expression of target genes (genomic action). Nongenomic mechanisms of action is initiated at the integrin receptor. The plasma membrane alpha(v)beta(3)-integrin has distinct binding sites for T3 and T4. One binding site binds only T3 and activates the phosphatidylinositol 3-kinase (PI3K) pathway. The other binding site binds both T3 and T4 and activates the ERK1/2 MAP kinase pathway.
Product List
Catalog
Product
Reactivity
Applications
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PRKACA (PT0438R) PT® Rabbit mAb
Human,Mouse,Rat,
WB,IHC,IF,IP,ELISA
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PKAα cat (Phospho Ser338) Rabbit pAb
Human,Mouse,Rat
IHC,IF,ELISA
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PKAβ Rabbit pAb
Human,Mouse,Rat
WB,IHC,IF,ELISA
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Total PKAβ cat Cell-Based Colorimetric ELISA Kit
Human,Mouse,Rat
ELISA
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PKAγ Rabbit pAb
Human
WB,IHC,IF,ELISA
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Integrin αV Rabbit pAb
Human,Mouse
WB,IHC,IF,ELISA
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Cleaved Integrin αV HC (Lys889) Rabbit pAb
Human,Rat,Mouse,
WB,ELISA
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Cleaved ITGAV (light chain,Asp891) Rabbit pAb
Human,Mouse
WB,ELISA,IHC
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Integrin β3 (PT0445R) PT® Rabbit mAb
Human,Mouse,Rat,
WB,IHC,IF,IP,ELISA
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CD61 (ABT032) Mouse mAb
Human,Mouse,
IHC,ELISA