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Prolactin signaling pathway
Prolactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and metabolism, brain and behavior, and immunomodulation. PRL mediates its action through PRLR, a transmembrane protein of the hematopoietin cytokine receptor superfamily. At the protein level, the long PRLR isoform (long-R) and several short PRLR isoforms (short-R) have been detected. Acting through the long-R, PRL activates many signaling cascades including Jak2/Stat, the major cascade, Src kinase, phosphatidylinositol-3-kinase (PI3K)/AKT, and mitogen-activated protein kinase (MAPK) pathways. PRL cannot activate Jak2/Stat5 through the short-R, but can activate pathways including MAPK and PI3K pathways.
Product List
    Catalog
    Product
    Reactivity
    Applications
  • Prolactin (ABT-PRL) Mouse mAb
    Human,
    IHC,IF,ELISA
  • Prolactin (ABT220) Mouse mAb
    Human,
    IHC,IF,ELISA
  • Prolactin (ABT-PRL) Mouse mAb (Ready to Use)
    Human,
    IHC
  • Prolactin (ABT220) Mouse mAb (Ready to Use)
    Human,
    IHC
  • Prolactin Rabbit pAb
    Human,Rat,Mouse,
    WB,IHC,IF,ELISA
  • Mouse PRL(Prolactin) ELISA Kit
    Mouse
    ELISA
  • Rat PRL(Prolactin) ELISA Kit
    Rat
    ELISA
  • Prolactin (ABT-PRL) IHC kit
    Human,
    IHC
  • Prolactin (ABT220) IHC kit
    Human,
    IHC
  • PRLR Rabbit pAb
    Human
    WB,ELISA
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