YTHD3 rabbit pAb

  • 货号：YT8102
  • 应用：IHC;WB
  • 种属：Human;Mouse
    • 靶点：
    • YTHDF3
    • 基因名称：
    • YTHDF3
    • 蛋白名称：
    • YTH domain family protein 3
    • Human Swiss Prot No：
    • Q7Z739
    • Mouse Swiss Prot No：
    • Q8BYK6
    • 免疫原：
    • Synthesized peptide derived from human N-ternal YTHD3
    • 特异性：
    • This antibody detects endogenous levels of YTHD3 at Human, Mouse
    • 组成：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • WB 1:500-2000 IHC 1:50-200
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称：
    • YTH domain family protein 3
    • 分子量：
    • 64kD
    • 功能：
    • Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing . Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 . The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation . Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-conta
    • 细胞定位：
    • Cytoplasm, cytosol . Cytoplasm, P-body . Cytoplasm, Stress granule .

    相关报价

    • 货号：
    • YT8102
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • ¥960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-07-25
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