• 靶点：
• STIM1

• 基因名称：
• STIM1 GOK

• 蛋白名称：
• Stromal interaction molecule 1

• Human Gene Id：
• 6786

• Human Swiss Prot No：
• Q13586

• Mouse Gene Id：
• 20866

• Mouse Swiss Prot No：
• P70302

• Rat Gene Id：
• 361618

• Rat Swiss Prot No：
• P84903

• 免疫原：
• Synthesized peptide derived from human N-ternal STIM1

• 特异性：
• This antibody detects endogenous levels of STIM1 at Human, Mouse,Rat

• 组成：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000 IHC 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Stromal interaction molecule 1

• 分子量：
• 75kD

• 功能：
• Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores . Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 . Involved in enamel formation . Activated following interaction with STIMATE, leading to promote STIM1 conformational switch .

• 细胞定位：
• Cell membrane; Single-pass type I membrane protein . Endoplasmic reticulum membrane; Single-pass type I membrane protein . Cytoplasm, cytoskeleton . Sarcoplasmic reticulum . Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane (PubMed:19249086, PubMed:16005298, PubMed:16208375, PubMed:18854159). Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Colocalizes with ORAI1 at the cell membrane (PubMed:27185316). Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316). .

• 组织表达：
• Ubiquitously expressed in various human primary cells and tumor cell lines.

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