HMGCL rabbit pAb

  • 货号:YT8089
  • 应用:IHC;WB
  • 种属:Human;Mouse;Rat
    • 靶点:
    • HMGCL
    • 基因名称:
    • HMGCL
    • 蛋白名称:
    • Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)
    • Human Gene Id:
    • 3155
    • Human Swiss Prot No:
    • P35914
    • Mouse Swiss Prot No:
    • P38060
    • 免疫原:
    • Synthesized peptide derived from human C-ternal HMGCL
    • 特异性:
    • This antibody detects endogenous levels of HMGCL at Human, Mouse,Rat
    • 组成:
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • 来源:
    • Polyclonal, Rabbit,IgG
    • 稀释:
    • WB 1:500-2000 IHC 1:50-200
    • 纯化工艺:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度:
    • 1 mg/ml
    • 储存:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称:
    • Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)
    • 分子量:
    • 36kD
    • 功能:
    • Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.
    • 细胞定位:
    • Mitochondrion matrix . Peroxisome . Unprocessed form is peroxisomal. .
    • 组织表达:
    • Highest expression in liver. Expressed in pancreas, kidney, intestine, testis, fibroblasts and lymphoblasts. Very low expression in brain and skeletal muscle. The relative expression of isoform 2 (at mRNA level) is highest in heart (30%), skeletal muscle (22%), and brain (14%).