CAMKK1/2 rabbit pAb

  • 货号：YT8012
  • 应用：WB
  • 种属：Human;Mouse;Rat
    • 靶点：
    • CAMKK1/2
    • 简介：
    • >>Alcoholism
    • 基因名称：
    • CAMKK1 CAMKKA
    • 蛋白名称：
    • CAMKK1/2
    • Human Swiss Prot No：
    • Q8N5S9
    • Mouse Swiss Prot No：
    • Q8VBY2
    • 免疫原：
    • Synthesized peptide derived from human CAMKK1/2
    • 特异性：
    • This antibody detects endogenous levels of CAMKK1/2 at Human, Mouse,Rat
    • 组成：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • WB 1:500-2000
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称：
    • Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha)
    • 分子量：
    • 56kD
    • 背景：
    • The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
    • 功能：
    • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.,domain:The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.,enzyme regulation:Activated by Ca(2+)/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Partially inhibited upon phosphorylation by PRCAKA/PKA (By similarity). May be regulated through phosphorylation by CAMK1 and CAMK4.,function:Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell de
    • 细胞定位：
    • Cytoplasm . Nucleus .
    • 组织表达：
    • Amygdala,Brain,

    相关报价

    • 货号：
    • YT8012
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • ¥960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-08-09
    订购

    相关产品