• 靶点：
• CD14

• 简介：
• >>MAPK signaling pathway;>>NF-kappa B signaling pathway;>>Phagosome;>>Toll-like receptor signaling pathway;>>Hematopoietic cell lineage;>>Alcoholic liver disease;>>Shigellosis;>>Salmonella infection;>>Pertussis;>>Legionellosis;>>Amoebiasis;>>Tuberculosis;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia;>>Lipid and atherosclerosis

• 基因名称：
• CD14

• 蛋白名称：
• CD14

• Human Gene Id：
• 929

• Human Swiss Prot No：
• P08571

• Mouse Gene Id：
• 12475

• Mouse Swiss Prot No：
• P10810

• Rat Gene Id：
• 60350

• Rat Swiss Prot No：
• Q63691

• 免疫原：
• Synthesized peptide derived from human CD14

• 特异性：
• This antibody detects endogenous levels of Human CD14

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:1000-2000 ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein;CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form;Monocyte differentiation antigen CD14, membrane-bound form]

• 分子量：
• 41kD

• 背景：
• The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010],

• 功能：
• function:Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.,online information:CD14 entry,similarity:Contains 11 LRR (leucine-rich) repeats.,subunit:Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.,tissue specificity:Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.,

• 细胞定位：
• Cell membrane ; Lipid-anchor, GPI-anchor . Secreted . Membrane raft . Golgi apparatus . Secreted forms may arise by cleavage of the GPI anchor. .

• 组织表达：
• Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

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