PAX6 rabbit pAb

  • 货号：YT7954
  • 应用：WB;ELISA
  • 种属：Human;Rat;Mouse;
    • 靶点：
    • PAX6
    • 简介：
    • >>Signaling pathways regulating pluripotency of stem cells;>>Maturity onset diabetes of the young
    • 基因名称：
    • PAX6 AN2
    • 蛋白名称：
    • PAX6
    • Human Gene Id：
    • 5080
    • Human Swiss Prot No：
    • P26367
    • Mouse Swiss Prot No：
    • P63015
    • 免疫原：
    • Synthesized peptide derived from human PAX6
    • 特异性：
    • This antibody detects endogenous levels of Human PAX6
    • 组成：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • WB 1:1000-2000 ELISA 1:5000-20000
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称：
    • Paired box protein Pax-6 (Aniridia type II protein;Oculorhombin)
    • 分子量：
    • 46kD
    • 背景：
    • This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015],
    • 功能：
    • developmental stage:Expressed in the developing eye and brain.,disease:Defects in PAX6 are a cause of autosomal dominant keratitis [MIM:148190]. It is an eye disorder characterized by corneal opacification and vascularization, and by foveal hypoplasia.,disease:Defects in PAX6 are a cause of bilateral optic nerve hypoplasia [MIM:165550]; also known as bilateral optic nerve aplasia. Inheritance is autosomal dominant.,disease:Defects in PAX6 are a cause of coloboma of optic nerve [MIM:120430].,disease:Defects in PAX6 are a cause of ectopia pupillae [MIM:129750]. It is a congenital eye malformation in which the pupils are displaced from their normal central position.,disease:Defects in PAX6 are a cause of foveal hypoplasia [MIM:136520]. Foveal hypoplasia can be isolated or associated with presenile cataract. Inheritance is autosomal dominant.,disease:Defects in PAX6 are a cause of Gillespie
    • 细胞定位：
    • Nucleus .; [Isoform 1]: Nucleus .; [Isoform 5a]: Nucleus .
    • 组织表达：
    • [Isoform 1]: Expressed in lymphoblasts. ; [Isoform 5a]: Weakly expressed in lymphoblasts.

    相关报价

    • 货号：
    • YT7954
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • ¥960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-11-23
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