• 靶点：
• UPAR

• 简介：
• >>Complement and coagulation cascades;>>Proteoglycans in cancer

• 基因名称：
• PLAUR MO3 UPAR

• 蛋白名称：
• U-PAR

• Human Gene Id：
• 5329

• Human Swiss Prot No：
• Q03405

• Mouse Gene Id：
• 18793

• Mouse Swiss Prot No：
• P35456

• Rat Gene Id：
• 50692

• Rat Swiss Prot No：
• P49616

• 免疫原：
• Synthesized peptide derived from human U-PAR

• 特异性：
• This antibody detects endogenous levels of Human U-PAR

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:1000-2000 ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Urokinase plasminogen activator surface receptor (U-PAR;uPAR;Monocyte activation antigen Mo3;CD antigen CD87)

• 分子量：
• 37kD

• 背景：
• function:Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.,similarity:Contains 3 UPAR/Ly6 domains.,subunit:Monomer (Probable). Interacts with MRC2.,

• 功能：
• protein amino acid lipidation, GPI anchor metabolic process, GPI anchor biosynthetic process, phospholipid metabolic process, glycerophospholipid metabolic process, cell motion, chemotaxis, blood coagulation, hemostasis, behavior,locomotory behavior, lipid biosynthetic process, phospholipid biosynthetic process, response to wounding, attachment of GPI anchor to protein, organophosphate metabolic process, regulation of proteolysis, phosphoinositide metabolic process, regeneration, growth, wound healing, lipoprotein metabolic process, lipoprotein biosynthetic process, tissue regeneration, taxis, skeletal muscle regeneration, glycerolipid biosynthetic process, glycerophospholipid biosynthetic process, glycerolipid metabolic process, phosphoinositide biosynthetic process, developmental growth, coagulation,regulation of body fluid levels,

• 细胞定位：
• Cell membrane . Cell projection, invadopodium membrane . Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. .; [Isoform 1]: Cell membrane ; Lipid-anchor, GPI-anchor .; [Isoform 2]: Secreted .

• 组织表达：
• Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

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