• 靶点：
• IL23A

• 简介：
• >>Cytokine-cytokine receptor interaction;>>C-type lectin receptor signaling pathway;>>JAK-STAT signaling pathway;>>Th17 cell differentiation;>>Pertussis;>>Tuberculosis;>>Pathways in cancer;>>Inflammatory bowel disease;>>Rheumatoid arthritis

• 基因名称：
• IL23A

• 蛋白名称：
• IL23A

• Human Swiss Prot No：
• Q9NPF7

• 免疫原：
• Synthesized peptide derived from human IL23A

• 特异性：
• This antibody detects endogenous levels of Human IL23A

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:1000-2000 ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Interleukin-23 subunit alpha (IL-23 subunit alpha;IL-23-A;Interleukin-23 subunit p19;IL-23p19)

• 分子量：
• 21kD

• 背景：
• developmental stage:Expressed by newborns dendritic cells.,function:Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.,induction:Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.,similarity:Belongs to the IL-6 superfamily.,subcellular location:Secreted upon association with IL12B.,subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.,tissue specificity:Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).,

• 功能：
• cell activation, defense response, inflammatory response, immune response, cell proliferation, response to wounding,response to virus, mononuclear cell proliferation, T cell proliferation, T cell activation, innate immune response,leukocyte activation, lymphocyte activation, lymphocyte proliferation, tissue remodeling, leukocyte proliferation,

• 细胞定位：
• Secreted . Secreted upon association with IL12B.

• 组织表达：
• Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).

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