• 靶点：
• I-TAC

• 简介：
• >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>Toll-like receptor signaling pathway

• 基因名称：
• CXCL11 ITAC SCYB11 SCYB9B

• 蛋白名称：
• I-TAC

• Human Gene Id：
• 6373

• Human Swiss Prot No：
• O14625

• Mouse Gene Id：
• 56066

• Mouse Swiss Prot No：
• Q9JHH5

• 免疫原：
• Synthesized peptide derived from human I-TAC AA range: 45-94

• 特异性：
• This antibody detects endogenous levels of Human I-TAC

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• C-X-C motif chemokine 11 (Beta-R1;H174;Interferon gamma-inducible protein 9;IP-9;Interferon-inducible T-cell alpha chemoattractant;I-TAC;Small-inducible cytokine B11)

• 分子量：
• 10kD

• 背景：
• disease:Expressed in a variety of skin disorders, including allergic contact dermatitis, lichen planus and mycosis fungoides.,function:Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.,induction:By interferon gamma and interferon beta. Induction by IFN-gamma is enhanced by TNF-alpha in monocytes, dermal fibroblasts and endothelial cells, and by IL-1 in astrocytes.,mass spectrometry: PubMed:10233762,online information:CXCL11 entry,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,tissue specificity:High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.,

• 功能：
• chemotaxis, defense response, inflammatory response, immune response, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, cell-cell signaling, behavior, locomotory behavior,response to wounding, taxis,

• 细胞定位：
• Secreted.

• 组织表达：
• High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

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