• 靶点：
• PD1

• 简介：
• >>Cell adhesion molecules;>>T cell receptor signaling pathway;>>PD-L1 expression and PD-1 checkpoint pathway in cancer

• 基因名称：
• PDCD1 PD1

• 蛋白名称：
• Pdcd-1

• Human Gene Id：
• 5133

• Human Swiss Prot No：
• Q15116

• Mouse Gene Id：
• 18566

• Mouse Swiss Prot No：
• Q02242

• 免疫原：
• Synthesized peptide derived from human Pdcd-1 AA range: 80-130

• 特异性：
• This antibody detects endogenous levels of Human Pdcd-1

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Programmed cell death protein 1 (Protein PD-1;hPD-1;CD antigen CD279)

• 分子量：
• 32kD

• 背景：
• This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],

• 功能：
• developmental stage:Induced at programmed cell death.,disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,

• 细胞定位：
• Cell membrane ; Single-pass type I membrane protein.

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