• 靶点：
• Kir4.1

• 简介：
• >>Gastric acid secretion;>>Huntington disease

• 基因名称：
• KCNJ10

• 蛋白名称：
• Kir4.1

• Human Gene Id：
• 3766

• Human Swiss Prot No：
• P78508

• Mouse Gene Id：
• 16513

• Mouse Swiss Prot No：
• Q9JM63

• Rat Gene Id：
• 29718

• Rat Swiss Prot No：
• P49655

• 免疫原：
• Synthesized peptide derived from human Kir4.1 AA range: 160-240

• 特异性：
• This antibody detects endogenous levels of Human,Rat,Mouse Kir4.1

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ATP-sensitive inward rectifier potassium channel 10 (ATP-dependent inwardly rectifying potassium channel Kir4.1;Inward rectifier K(+) channel Kir1.2;Potassium channel, inwardly rectifying subfamily J member 10)

• 分子量：
• 42kD

• 背景：
• This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008],

• 功能：
• function:May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Seems to form heterodimer with Kir5.1/KCNJ16. Interacts with INADL.,

• 细胞定位：
• Membrane ; Multi-pass membrane protein. Basolateral cell membrane . In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16. .

• 组织表达：
• Expressed in kidney (at protein level).

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