• 靶点：
• ANGPTL3

• 简介：
• >>Cholesterol metabolism

• 基因名称：
• ANGPTL3 ANGPT5 UNQ153/PRO179

• 蛋白名称：
• ANGPTL3

• Human Gene Id：
• 27329

• Human Swiss Prot No：
• Q9Y5C1

• Mouse Gene Id：
• 30924

• Mouse Swiss Prot No：
• Q9R182

• 免疫原：
• Synthesized peptide derived from human ANGPTL3 AA range: 50-130

• 特异性：
• This antibody detects endogenous levels of Human ANGPTL3

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:1000-2000 ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Angiopoietin-related protein 3 (Angiopoietin-5;ANG-5;Angiopoietin-like protein 3)

• 分子量：
• 51kD

• 背景：
• similarity:Contains 1 fibrinogen C-terminal domain.,tissue specificity:Expressed principally in liver. Weakly expressed in kidney.,

• 功能：
• blood vessel development, vasculature development, glycerol metabolic process, fatty acid metabolic process,phospholipid metabolic process, cell adhesion, cell-matrix adhesion, cell surface receptor linked signal transduction,integrin-mediated signaling pathway, steroid metabolic process, cholesterol metabolic process, phospholipid catabolic process, regulation of catabolic process, positive regulation of catabolic process, regulation of phospholipase activity,negative regulation of phospholipase activity, lipid localization, lipid catabolic process, sterol metabolic process,regulation of lipid metabolic process, alditol metabolic process, organophosphate metabolic process, polyol metabolic process, lipid storage, biological adhesion, regulation of cell migration, positive regulation of cell migration, cell-substrate adhesion, regulation of locomotion, positive regulation of locomotion, 

• 细胞定位：
• Secreted . Cell projection, lamellipodium . Colocalized with HSPG2 and activated ITGB3 on podocytes. .

• 组织表达：
• Expressed principally in liver. Weakly expressed in kidney. Binds to adipocytes. Increased expression and colocalization with activated ITGB3 in glomeruli of patients with nephrotic syndrome showing effaced podocyte foot processes (at protein level).

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