DCNL3 rabbit pAb

    • 货号:YT7767
    • 应用:WB
    • 种属:Human;Mouse;Rat
      • 靶点:
      • DCNL3
      • 基因名称:
      • DCUN1D3
      • 蛋白名称:
      • DCNL3
      • Human Swiss Prot No:
      • Q8IWE4
      • Mouse Swiss Prot No:
      • Q8K0V2
      • 免疫原:
      • Synthesized peptide derived from human DCNL3 AA range: 205-255
      • 特异性:
      • This antibody detects endogenous levels of DCNL3 at Human/Mouse/Rat
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500-2000
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 分子量:
      • 33kD
      • 功能:
      • similarity:Contains 1 DCUN1 domain.,
      • 细胞定位:
      • Cell membrane . Cytoplasm . Nucleus . Cytoplasm, perinuclear region . After UVC treatment, the protein enters to the nucleus gradually (PubMed:18823379). Cell membrane localization is essential for CUL3 neddylation (PubMed:19617556). .
      • 组织表达:
      • Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma (PubMed:25349211). Mostly expressed in testis and brain (PubMed:26906416). Highly expressed in liver, bladder and renal normal tissue than their tumor tissue counterparts (PubMed:18823379). Palmitoylation stabilizes DCUN1D3 at the cell membrane (PubMed:19617556).
      • 产品图片
      • Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night