• 靶点：
• EVI5

• 基因名称：
• EVI5 NB4S

• 蛋白名称：
• EVI5

• Human Gene Id：
• 7813

• Human Swiss Prot No：
• O60447

• Mouse Swiss Prot No：
• P97366

• 免疫原：
• Synthesized peptide derived from human EVI5 AA range: 1-51

• 特异性：
• This antibody detects endogenous levels of EVI5 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 89kD

• 功能：
• disease:A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated.,function:Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.,induction:Down-regulated during mitosis through proteasomal degradation.,miscellaneous:Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities.,PTM:Probably phosphorylated by PLK1; may be required for degradation during mitosis.,PTM:Ubiquitinated. Degradation during prophase is ubiquitin-dependent.,similarity:Contains 1 Rab-GAP TBC domain.,subcellular location:Associates with the mitotic spindle through anaphase and remains within the midzone and

• 细胞定位：
• Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.

• 组织表达：
• Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.

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