• 靶点：
• PRGC2

• 简介：
• >>Insulin resistance

• 基因名称：
• PPARGC1B PERC PGC1 PGC1B PPARGC1

• 蛋白名称：
• PRGC2

• Human Gene Id：
• 133522

• Human Swiss Prot No：
• Q86YN6

• Mouse Gene Id：
• 170826

• Mouse Swiss Prot No：
• Q8VHJ7

• Rat Gene Id：
• 291567

• Rat Swiss Prot No：
• Q811R2

• 免疫原：
• Synthesized peptide derived from human PRGC2 AA range: 829-879

• 特异性：
• This antibody detects endogenous levels of PRGC2 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 113kD

• 背景：
• The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],

• 功能：
• domain:Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.,function:Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure.,induction:Repressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as w

• 细胞定位：
• Nucleus .

• 组织表达：
• Ubiquitous with higher expression in heart, brain and skeletal muscle.

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