• 靶点：
• CXXC4

• 简介：
• >>Wnt signaling pathway

• 基因名称：
• CXXC4 IDAX

• 蛋白名称：
• CXXC4

• Human Gene Id：
• 80319

• Human Swiss Prot No：
• Q9H2H0

• Mouse Gene Id：
• 319478

• Mouse Swiss Prot No：
• Q6NXI8

• Rat Gene Id：
• 83824

• Rat Swiss Prot No：
• Q9EQC9

• 免疫原：
• Synthesized peptide derived from human CXXC4 AA range: 15-65

• 特异性：
• This antibody detects endogenous levels of CXXC4 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 22kD

• 背景：
• This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

• 功能：
• function:Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.,similarity:Contains 1 CXXC-type zinc finger.,subunit:Interacts with the PDZ domain of DVL1.,

• 细胞定位：
• Cytoplasm .

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