• 靶点：
• ZFP57

• 简介：
• >>Herpes simplex virus 1 infection

• 基因名称：
• ZFP57 C6orf40 ZNF698

• 蛋白名称：
• ZFP57

• Human Gene Id：
• 346171

• Human Swiss Prot No：
• Q9NU63

• Mouse Gene Id：
• 22715

• Mouse Swiss Prot No：
• Q8C6P8

• Rat Gene Id：
• 361783

• Rat Swiss Prot No：
• A0JPK3

• 免疫原：
• Synthesized peptide derived from human ZFP57 AA range: 373-423

• 特异性：
• This antibody detects endogenous levels of ZFP57 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 50kD

• 背景：
• The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009],

• 功能：
• disease:Defects in ZFP57 are the cause of transient neonatal diabetes mellitus type 1 (TNDM1) [MIM:601410]. Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. The major cause of TNDM1 is aberrant expression of imprinted genes at chromosome 6q24, associated in 20% of cases with DNA hypomethylation at the transient neonatal diabetes differentially methylated region (DMR), which lies within the imprinted promoter of the PLAGL1 gene. Over 50% of individuals with transient neonatal diabetes and hypomethylation at 6q24 also show mosaic DNA hypomethylation at other imprinted loci throughout the genome and a range of additional clinical features.,domain:The KRAB domain

• 细胞定位：
• Nucleus . Binds various differentially methylated regions (DMR). .

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