• 靶点：
• SEN15

• 基因名称：
• TSEN15 C1orf19 SEN15

• 蛋白名称：
• SEN15

• Human Gene Id：
• 116461

• Human Swiss Prot No：
• Q8WW01

• Mouse Gene Id：
• 66637

• Mouse Swiss Prot No：
• Q8R3W5

• 免疫原：
• Synthesized peptide derived from human SEN15 AA range: 84-134

• 特异性：
• This antibody detects endogenous levels of SEN15 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 19kD

• 背景：
• This gene encodes a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17. [provided by RefSeq, Jul 2014],

• 功能：
• caution:Although only weakly related to the S.cerevisiae SEN15 protein, it probably displays the same function within the tRNA splicing endonuclease complex.,function:Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3' end processing factors, establishing a link between pre-tRNA splicing and p

• 细胞定位：
• Nucleus . Nucleus, nucleolus . May be transiently localized in the nucleolus. .

• 组织表达：
• Widely expressed. Highly expressed in testis and uterus.

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