• 靶点：
• SAP18

• 简介：
• >>Nucleocytoplasmic transport;>>mRNA surveillance pathway

• 基因名称：
• SAP18 GIG38

• 蛋白名称：
• SAP18

• Human Gene Id：
• 10284

• Human Swiss Prot No：
• O00422

• Mouse Gene Id：
• 20220

• Mouse Swiss Prot No：
• O55128

• 免疫原：
• Synthesized peptide derived from human SAP18

• 特异性：
• This antibody detects endogenous levels of SAP18 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 17kD

• 背景：
• Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008],

• 功能：
• function:Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins.,similarity:Belongs to the SAP18 family.,subunit:Forms a complex with SIN3A and HDAC1.,tissue specificity:Ubiquitous.,

• 细胞定位：
• Nucleus . Cytoplasm . Nucleus speckle . Shuttles between the nucleus and the cytoplasm (PubMed:16314458). Colocalizes with ACIN1 and SRSF2 in nuclear speckles (PubMed:20966198). .

• 组织表达：
• Ubiquitous.

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