• 靶点：
• FHOD1

• 简介：
• >>Salmonella infection

• 基因名称：
• FHOD1 FHOS FHOS1

• 蛋白名称：
• FHOD1

• Human Gene Id：
• 29109

• Human Swiss Prot No：
• Q9Y613

• Mouse Gene Id：
• 234686

• Mouse Swiss Prot No：
• Q6P9Q4

• 免疫原：
• Synthesized peptide derived from human FHOD1 AA range: 210-260

• 特异性：
• This antibody detects endogenous levels of FHOD1 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 128kD

• 背景：
• This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],

• 功能：
• domain:Regulated by intramolecular binding to a C-terminal auto-inhibitory domain. Effector binding abolishes this interaction and activates the protein.,function:Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation.,similarity:Belongs to the formin homology family.,similarity:Contains 1 FH1 (formin homology 1) domain.,similarity:Contains 1 FH2 (formin homology 2) domain.,similarity:Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.,subcellular location:Predominantly cytoplasmic.,subunit:Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus.,tissue specificity:Ubiquitous. Highly expressed in spleen.,

• 细胞定位：
• Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Predominantly cytoplasmic.

• 组织表达：
• Ubiquitous. Highly expressed in spleen.

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