• 靶点：
• GRIK3

• 简介：
• >>Neuroactive ligand-receptor interaction;>>Glutamatergic synapse

• 基因名称：
• GRIK3 GLUR7

• 蛋白名称：
• GRIK3

• Human Gene Id：
• 2899

• Human Swiss Prot No：
• Q13003

• Mouse Gene Id：
• 14807

• Mouse Swiss Prot No：
• B1AS29

• Rat Gene Id：
• 298521

• Rat Swiss Prot No：
• P42264

• 免疫原：
• Synthesized peptide derived from human GRIK3 AA range: 209-259

• 特异性：
• This antibody detects endogenous levels of GRIK3 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 101kD

• 背景：
• Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008],

• 功能：
• function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.,RNA editing:Partially edited.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Homomeric. Can also coassemble with either GRIK4 or GRIK5 to form heteromeric receptors. Interacts with PRKCABP.,

• 细胞定位：
• Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

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