• 靶点：
• VIP2

• 简介：
• >>Phosphatidylinositol signaling system

• 基因名称：
• PPIP5K2 HISPPD1 KIAA0433 VIP2

• 蛋白名称：
• VIP2

• Human Gene Id：
• 23262

• Human Swiss Prot No：
• O43314

• Mouse Gene Id：
• 227399

• Mouse Swiss Prot No：
• Q6ZQB6

• 免疫原：
• Synthesized peptide derived from human VIP2 AA range: 266-316

• 特异性：
• This antibody detects endogenous levels of VIP2 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 137kD

• 背景：
• This gene encodes a member of the histidine acid phosphatase family of proteins. Despite containing a histidine acid phosphatase domain, the encoded protein functions as an inositol pyrophosphate kinase, and is thought to lack phosphatase activity. This kinase activity is the mechanism by which the encoded protein synthesizes high-energy inositol pyrophosphates, which act as signaling molecules that regulate cellular homeostasis and other processes. This gene may be associated with autism spectrum disorder in human patients. [provided by RefSeq, Sep 2016],

• 功能：
• catalytic activity:ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown).,catalytic activity:ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown).,catalytic activity:ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.,caution:Although related to histidine acid phosphatases, it lacks the conserved active sites, suggesting that it has no phosphatase activity.,function:Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP-InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2-InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates

• 细胞定位：
• Cytoplasm, cytosol .

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