• 靶点：
• ZMIZ2

• 基因名称：
• ZMIZ2 KIAA1886 ZIMP7 HRIHFB2007

• 蛋白名称：
• ZMIZ2

• Human Gene Id：
• 83637

• Human Swiss Prot No：
• Q8NF64

• Mouse Gene Id：
• 52915

• Mouse Swiss Prot No：
• Q8CIE2

• 免疫原：
• Synthesized peptide derived from human ZMIZ2 AA range: 512-562

• 特异性：
• This antibody detects endogenous levels of ZMIZ2 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 101kD

• 背景：
• ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010],

• 功能：
• domain:The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.,function:Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.,similarity:Contains 1 SP-RING-type zinc finger.,subcellular location:Detected at replication foci throughout S phase.,subunit:Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.,tissue specificity:Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.,

• 细胞定位：
• Nucleus . Detected at replication foci throughout S phase.

• 组织表达：
• Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.

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