• 靶点：
• HERC3

• 简介：
• >>Ubiquitin mediated proteolysis

• 基因名称：
• HERC3 KIAA0032

• 蛋白名称：
• HERC3

• Human Gene Id：
• 8916

• Human Swiss Prot No：
• Q15034

• 免疫原：
• Synthesized peptide derived from human HERC3 AA range: 985-1035

• 特异性：
• This antibody detects endogenous levels of HERC3 at Human

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 116kD

• 背景：
• This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012],

• 功能：
• function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinated; which promotes degradation by the proteasome.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 7 RCC1 repeats.,subcellular location:Also found in vesicular-like structures.,

• 细胞定位：
• Cytoplasm. Cytoplasmic vesicle. Also found in vesicular-like structures.

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