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WB 试剂
- PonceauS Staining Solution
- PBST Washing Buffer, 10X
- 1.5M Tris-HCl Buffer, pH8.8
- 1M Tris-HCl Buffer, pH6.8
- 10% SDS Solution
- Prestained Protein Marker
- TBST Washing Buffer, 10X
- SDS PAGE Loading Buffer, 5X
- Stripping Buffered Solution
- Tris Buffer, pH7.4, 10X
- Total Protein Extraction Kit
- Running Buffer, 10X
- Transfer Buffer, 10X
- 30% Acr-Bis(29:1) Solution
- Tris电泳液速溶颗粒
- PBS(1X, premixed powder)
- TBS(1X, premixed powder)
- 快速封闭液
- 转膜液速溶颗粒
- Chemical reagents
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UN13B rabbit pAb
- 货号:YT7120
- 应用:WB
- 种属:Human;Mouse;Rat
- 简介:
- >>Synaptic vesicle cycle
- 免疫原:
- Synthesized peptide derived from human UN13B AA range: 1325-1375
- 特异性:
- This antibody detects endogenous levels of UN13B at Human/Mouse/Rat
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 背景:
- This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008],
- 功能:
- domain:The C2 domains are not involved in calcium-dependent phospholipid binding.,function:Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.,similarity:Belongs to the unc-13 family.,similarity:Contains 1 MHD1 (MUNC13 homology domain 1) domain.,similarity:Contains 1 MHD2 (MUNC13 homology domain 2) domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 3 C2 domains.,subcellular location:Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.
- 细胞定位:
- Cytoplasm . Membrane ; Peripheral membrane protein . Cell membrane . Cell junction, synapse . Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). .
- 组织表达:
- Expressed in kidney cortical epithelial cells and brain.
![](/uploadfiles/PIC/YT7120wb-2019.jpg)
- Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night