• 靶点：
• M21D1

• 简介：
• >>Cytosolic DNA-sensing pathway;>>Shigellosis;>>Human cytomegalovirus infection;>>Herpes simplex virus 1 infection;>>Human immunodeficiency virus 1 infection;>>Coronavirus disease - COVID-19

• 基因名称：
• MB21D1 cGAS C6orf150

• 蛋白名称：
• M21D1

• Human Gene Id：
• 115004

• Human Swiss Prot No：
• Q8N884

• 免疫原：
• Synthesized peptide derived from human M21D1 AA range: 35-85

• 特异性：
• This antibody detects endogenous levels of M21D1 at Human

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 57kD

• 细胞定位：
• Nucleus . Chromosome . Cell membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Mainly localizes in the nucleus, and at low level in the cytosol (PubMed:31808743, PubMed:31544964). On chromosomes, enriched on centromeric satellite and LINE DNA repeat elements (PubMed:30811988). Exported from the nucleus to the cytosol in a XPO1/CRM1 via the nuclear export signal in response to DNA stimulation (PubMed:33406424). Outside the nucleus, localizes at the cell membrane as a peripheral membrane protein in resting conditions: association to the cell membrane is mediated via binding to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:30827685). Localization at the cell membrane is required to limit the recognition of self-DNA (PubMed:30827685). Following detection of double-st

• 组织表达：
• Expressed in the monocytic cell line THP1.

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