• 靶点：
• XPO4

• 简介：
• >>Nucleocytoplasmic transport

• 基因名称：
• XPO4 KIAA1721

• 蛋白名称：
• XPO4

• Human Gene Id：
• 64328

• Human Swiss Prot No：
• Q9C0E2

• Mouse Gene Id：
• 57258

• Mouse Swiss Prot No：
• Q9ESJ0

• 免疫原：
• Synthesized peptide derived from human XPO4 AA range: 244-294

• 特异性：
• This antibody detects endogenous levels of XPO4 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 127kD

• 背景：
• XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009],

• 功能：
• function:Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.,similarity:Belongs to the exportin family.,subcellular location:Shuttles between the nucleus and the cytoplasm.,subuni

• 细胞定位：
• Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm. .

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